$43,146
Raised of $70,605
Team CADASIL
Team Profile
Team participating in 2023 Million Dollar Bike Ride
Captained by Pedro de Lencastre
Embrace the Challenge With Us
CADASIL is a rare, autosomal dominant genetic disorder caused by a mutation of the NOTCH3 gene on the 19th chromosome. Hallmark symptoms of CADASIL may include: recurrent strokes, cognitive impairment, migraine with aura, and psychiatric disturbances. These symptoms are caused by damage to small blood vessels, especially those within the brain. The specific symptoms and severity of the disorder can vary greatly among affected individuals, even among members of the same family. Despite this variability, most individuals (approximately three out of four patients) experience recurrent stroke or transient ischemic attacks (TIAs), beginning at 40-50 years of age. CADASIL affects all races and both genders equally, each child of a parent with CADASIL has a 50% chance of having the disorder.
CADASIL is an acronym that stands for:
(C)erebral - relating to the brain
(A)utosomal (D)ominant - a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder
(A)rteriopathy - disease of the arteries (blood vessels that carry blood away from the heart)
(S)ubcortical - relating to specific areas of the brain supplied by deep small blood vessels
(I)nfarcts - tissue loss in the brain caused by lack of blood flow to the brain, which occurs when circulation through the small arteries is severely reduced or interrupted
(L)eukoencephalopathy - lesions in the brain white matter caused by the disease and observed on MRI.
Team Members 20
Fred Rodgers
The Carney's
Pedro de Lencastre
Karen Breault
Diane Smith
Contributions 203
Anonymous donated $50 to Thomas Brennan
18 hours ago
Matthew Kaufhold donated $25 to Thomas Brennan
Go, Tom, Go!
20 hours ago
Terry McMahon donated $25 to Thomas Brennan
23 hours ago
Nancy Maurer donated $100 to Fred Rodgers
In memory of Suzy. Condolences to her loving family.
1 day ago
Darcy Patai Harrington donated $25 to Thomas Brennan
1 day ago