Team CADASIL

In the past few years, Team CADASIL has raised nearly $700,000 for Cadasil researchers through the Million Dollar Bike Ride. The funds enable researchers to conduct studies and collect preliminary data, which can lead to larger grants and future clinical trials. This is vital for developing treatments and understanding the natural history of CADASIL.

Team CADASIL will be riding again this year to raise funds for research. This year, we will be hosting our own donation page so that all donations will go directly to CADASIL research with no fees. Please follow the instructions below so that 100% of every dollar raised is directed to research. Watch walkthrough here.

STEPS for In-Person Participation in Philly:

1. Register here.

2. If you are cycling, choose "In-Person Cyclist - Fundraising Optional," and click "Select." On next page, de-select "Create a Fundraising Page" and complete process.

3. If you are walking, choose "Million Dollar Mile" and click "Select." On next page, de-select "Create a Fundraising Page" and complete process.

4. Create a fundraising page here. This will ensure that we dont pay fees for every donation.

If you have any questions, please contact cureCADASIL at info@curecadasil.org or your Team Captain, pedro@curecadasil.org

CADASIL is a rare, autosomal dominant genetic disorder caused by a mutation of the NOTCH3 gene on the 19th chromosome. Hallmark symptoms of CADASIL may include: recurrent strokes, cognitive impairment, migraine with aura, and psychiatric disturbances. These symptoms are caused by damage to small blood vessels, especially those within the brain. The specific symptoms and severity of the disorder can vary greatly among affected individuals, even among members of the same family. Despite this variability, most individuals (approximately three out of four patients) experience recurrent stroke or transient ischemic attacks (TIAs), beginning at 40-50 years of age. CADASIL affects all races and both genders equally, each child of a parent with CADASIL has a 50% chance of having the disorder.

CADASIL is an acronym that stands for:

(C)erebral - relating to the brain

(A)utosomal (D)ominant - a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder

(A)rteriopathy - disease of the arteries (blood vessels that carry blood away from the heart)

(S)ubcortical - relating to specific areas of the brain supplied by deep small blood vessels

(I)nfarcts - tissue loss in the brain caused by lack of blood flow to the brain, which occurs when circulation through the small arteries is severely reduced or interrupted

(L)eukoencephalopathy - lesions in the brain white matter caused by the disease and observed on MRI.